Home Genetic Tests Clinical Genomics Sickle Cell Anemia Screening
Clinical · Haematology
HBB Gene · Sanger Sequencing

Sickle Cell Anemia Screening

Know Your HbS Status. Protect Your Family From a Preventable Crisis.

Sickle cell anemia affects approximately 300,000 newborns every year globally — a number projected to exceed 400,000 by 2050. In India, it disproportionately affects tribal communities and populations of Central and Western India. A single mutation in the HBB gene causes red blood cells to take a rigid, sickle-like shape — blocking blood vessels, starving tissues of oxygen, and causing severe pain crises, organ damage, and life-threatening complications. This Sanger sequencing test detects the HbS mutation to determine your carrier or affected status — critical knowledge for family planning and early intervention.

★★★★★
5.0 (Verified clinical test) NABL & CAP lab
Sample type
Blood + Saliva
Turnaround
3–4 weeks
Gene analyzed
HBB gene (HbS)
Technology
Sanger Sequencing
Sickle Cell Anemia HBB Gene Test
Normal RBCs vs Sickle Cells — What changes
✓ Normal Red Blood Cells
Smooth, round, flexible shape
Lifespan: 90–120 days
Flows freely through blood vessels
Efficient oxygen transport
No clumping or blockages
✗ Sickle Cells (HbS)
Rigid, crescent/sickle shape
Lifespan: only 10–20 days
Gets stuck in small vessels
Poor oxygen delivery → anemia
Causes pain crises & organ damage
What you'll discover

HbS mutation status

Whether you carry one copy (sickle cell trait) or two copies (sickle cell disease) of the HbS mutation

HBB gene analysis

Family planning risk

If both partners are carriers, each child has 25% risk of sickle cell disease — critical knowledge before starting a family

Reproductive risk

Pain crisis risk

Understanding your disease severity helps predict and prevent vaso-occlusive pain crises with proactive care

Crisis prevention

Infection & organ risk

Sickle cells damage the spleen over time, increasing infection risk — early knowledge enables preventive vaccinations

Prevention planning

Newborn screening

Early diagnosis enables life-saving interventions — penicillin prophylaxis, vaccinations, and monitoring from infancy

Early intervention

Treatment guidance

Hydroxyurea therapy, transfusion management, bone marrow transplant eligibility — guided by confirmed diagnosis

Personalized care
How it works
1

Order online

Place your order. Home collection kit ships within 24 hours — EDTA blood tube and saliva swab included.

2

Blood + Saliva sample collection

2ml EDTA blood + saliva swab at home. Return using prepaid courier label included in your kit.

3

HBB gene Sanger sequencing

HbS mutation in the HBB gene analyzed using Sanger sequencing in our NABL & CAP accredited lab.

4

Report + consultation

Detailed sickle cell carrier report in 3–4 weeks — with HbS genotype, carrier/affected status, and personalized recommendations for care and family planning.

Sample report preview

Your Sickle Cell Anemia Report

A snapshot of your HBB gene sickle cell screening report

HbS Status
Carrier
Sickle cell trait (HbAS)
Genotype
HbAS
Heterozygous carrier
Disease Status
Trait
Generally asymptomatic
Child Risk
25%
If partner also carrier
HbS genotype (AA/AS/SS)
Carrier / Affected / Clear
Zygosity analysis
Child risk calculation
Family planning guidance
Clinician-ready report
Frequently asked questions
Who should consider sickle cell testing?
Sickle cell testing is recommended for individuals of African, Mediterranean, Middle Eastern, Caribbean, and South/Southeast Asian descent — all high-prevalence populations. In India, tribal communities of Madhya Pradesh, Chhattisgarh, Odisha, Maharashtra, and Gujarat have high carrier rates. Testing is essential for couples planning to have children, individuals with unexplained anemia or pain crises, newborn screening, and anyone with a family history of sickle cell disease.
What is the difference between sickle cell trait and sickle cell disease?
Sickle cell trait (HbAS) means you inherited one normal hemoglobin gene and one HbS gene — you are a carrier. Carriers are generally healthy and typically don't experience sickle cell symptoms, though they may face complications in extreme conditions (severe dehydration, very high altitude, or extreme exercise). Sickle cell disease (HbSS) means you inherited two HbS genes — one from each parent — and will experience the full range of sickle cell complications including pain crises, anemia, and organ damage.
What happens if both parents are carriers?
If both parents carry sickle cell trait (HbAS), each pregnancy has a 25% chance of sickle cell disease (HbSS), a 50% chance of sickle cell trait (HbAS), and a 25% chance of normal hemoglobin (HbAA). Couples in this situation can consider preimplantation genetic diagnosis (PGD) during IVF, prenatal diagnosis, or natural conception with prenatal testing. Our Genomic Expert can guide you through the options.
How is sickle cell disease managed?
Management includes pain management for crises, hydroxyurea medication to reduce sickling and complications, regular blood transfusions in severe cases, penicillin prophylaxis to prevent infections (especially in children), vaccinations, and folic acid supplementation. Bone marrow or stem cell transplantation offers a potential cure for eligible patients. Early diagnosis through newborn screening enables these life-saving interventions from infancy.
Is my data safe?
Yes. All data is protected under ISO 27001, HIPAA, and GDPR standards. Never shared with insurance companies, employers, or third parties without your consent. You retain full ownership of your genetic information.
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🧬 Clinical Genomics · Haematology
₹4,000
  • HbS mutation detection (HBB gene)
  • Genotype: HbAA / HbAS / HbSS
  • Carrier / Affected / Clear status
  • Zygosity analysis
  • NABL & CAP accredited lab
  • Family planning guidance included
Quantity
1
Secure checkout · SSL encrypted
Free pan-India shipping
Results in 3–4 weeks
Data never shared with insurers
NABL & CAP accredited
Genomic Expert Consultation — Available
After results, our Genomic Expert can guide family planning and connect you with haematology specialists if needed.
Appointment link sent via email after order confirmation.
NABL & CAP

Accredited lab

Sanger Sequencing

HBB gene analysis

Family Planning

Carrier risk guidance

ISO 27001

Data security

100% Private

GDPR compliant

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