Clinical · Prenatal
cfDNA · NGS · From 10 Weeks
✦ Plus 5 Microdeletions
NIPT Plus Microdeletions
Everything in Standard NIPT — Plus 5 Microdeletion Syndromes. The Most Comprehensive Prenatal Screen.
NIPT Plus takes prenatal chromosomal screening to the next level. Built on the same safe, accurate, non-invasive cell-free DNA technology as standard NIPT — performed from just 10ml of maternal blood with >99% accuracy — NIPT Plus additionally screens for 5 rare microdeletion syndromes including DiGeorge syndrome, Prader-Willi, Angelman, Cri-du-chat, and Wolf-Hirschhorn syndrome. These conditions are often missed by standard NIPT and ultrasound, making NIPT Plus the most comprehensive prenatal chromosomal screening available.
PCPNDT Compliance: As per PCPNDT Act, this test does not reveal the sex of the fetus. Sex chromosome aneuploidies are reported in terms of clinical risk only.
Upgrade from Standard NIPT — includes everything in NIPT (T21, T18, T13 + sex chromosome aneuploidies) PLUS 5 additional microdeletion syndromes for just ₹7,000 more.
Sample type
Maternal Blood
Turnaround
2–3 weeks
Earliest testing
10 weeks
Conditions
Trisomies + 5 micro
NIPT Plus Microdeletions
What's included in NIPT Plus
✓ Standard NIPT (included)
Trisomy 21 — Down Syndrome
Trisomy 18 — Edwards Syndrome
Trisomy 13 — Patau Syndrome
Sex chromosome aneuploidies
cfDNA fraction analysis
✦ Plus 5 Microdeletions (new)
DiGeorge syndrome (22q11.2)
Prader-Willi syndrome (15q11)
Angelman syndrome (15q11)
Cri-du-chat syndrome (5p15)
Wolf-Hirschhorn syndrome (4p16.3)
5 microdeletion syndromes explained
Chromosome 22q11.2
DiGeorge Syndrome
Heart defects, immune problems, facial features, mild-to-moderate intellectual disability. 1 in 5 develop autism; 1 in 4 adults develop schizophrenia.
1 in 2,000 births
Chromosome 15q11
Prader-Willi Syndrome
Low muscle tone, feeding difficulties in infancy, later obesity, short stature, delayed milestones, intellectual disability.
1 in 10,000 births
Chromosome 15q11
Angelman Syndrome
Severe intellectual disability, speech impairment, movement difficulties, frequent smiling/laughing, seizures.
1 in 12,000 births
Chromosome 5p15
Cri-du-chat Syndrome
High-pitched cry (like a cat), small head, wide-spaced eyes, intellectual disability, developmental delays.
1 in 20,000 births
5th microdeletion screened:
Wolf-Hirschhorn syndrome (4p16.3) — Intellectual disability, seizures, growth deficiency, characteristic facial features. 1 in 50,000 births.
How it works
1
Confirm gestational age
NIPT Plus can be performed from 10 weeks of pregnancy. Confirm gestational age with your OB-GYN before ordering.
2
Order with referral confirmation
Confirm doctor's referral. Your kit ships within 24 hours — includes Streck tube for maternal blood collection.
3
Maternal blood collection
10 ml maternal blood in Streck tube — at home or nearby lab. Non-invasive, no risk to baby, no fasting required.
4
cfDNA + microdeletion NGS analysis
Cell-free fetal DNA analyzed for trisomies AND scanned for microdeletion regions at targeted chromosomal loci using high-depth NGS in our NABL & CAP lab.
5
Results + Genomic Expert consultation
Comprehensive NIPT Plus report in 2–3 weeks. Our Genomic Expert reviews all findings with you — trisomy risks and microdeletion screen results explained clearly.
Sample report preview
Your NIPT Plus Report
A snapshot of your comprehensive prenatal chromosomal + microdeletion screening report
Trisomy 21/18/13
Low Risk
All three trisomies screened
Sex Chromosome
Low Risk
Aneuploidies screened
DiGeorge (22q11.2)
Low Risk
Microdeletion screened
All 5 Microdeletions
Low Risk
All syndromes screened
T21, T18, T13 risk scores
5 microdeletion risk scores
Sex chromosome report
cfDNA fraction analysis
OB-GYN ready report
PCPNDT compliant
Frequently asked questions
What is the difference between NIPT and NIPT Plus?
Standard NIPT screens for the three most common trisomies (T21, T18, T13) and sex chromosome aneuploidies with >99% accuracy. NIPT Plus includes everything in standard NIPT and additionally screens for 5 rare microdeletion syndromes: DiGeorge, Prader-Willi, Angelman, Cri-du-chat, and Wolf-Hirschhorn. These microdeletions affect about 1 in 1,000 pregnancies collectively and are often missed by standard ultrasound and routine prenatal screening.
Are microdeletions as accurately detected as trisomies?
Microdeletion detection has lower sensitivity than trisomy detection due to the smaller size of the missing DNA segments. DiGeorge syndrome (22q11.2) has the highest detection rate of approximately 92%, while other microdeletions vary. The positive predictive value (PPV) for microdeletions is also lower than for trisomies — meaning more confirmatory testing may be needed after a high-risk result. Your Genomic Expert will explain this in detail during your post-result consultation.
Who should choose NIPT Plus over standard NIPT?
NIPT Plus is recommended for parents who want the most comprehensive non-invasive prenatal chromosomal screening available, those with a family history of any of the 5 microdeletion syndromes, advanced maternal age, or any history of abnormal ultrasound findings. Many genetic counselors now recommend NIPT Plus as the preferred first-line prenatal screen because microdeletion syndromes are not otherwise detectable non-invasively.
How is the sample collected?
Same as standard NIPT — 10 ml of maternal blood in a Streck tube. This can be collected at home with a trained phlebotomist or at any nearby pathology lab. The Streck tube preserves cell-free fetal DNA during transport. No fasting required, no risk to the baby.
Is my data private and is the test PCPNDT compliant?
Yes on both counts. Your data is protected under ISO 27001, HIPAA, and GDPR standards. And we strictly comply with the PCPNDT Act — the sex of the fetus is never revealed, and sex chromosome results are reported only in terms of chromosomal health risk.
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🤱 Clinical · Prenatal Plus
₹25,000
- T21, T18, T13 + sex chromosome screening
- 5 microdeletion syndromes screened
- DiGeorge, Prader-Willi, Angelman, Cri-du-chat, Wolf-Hirschhorn
- Results in 2–3 weeks
- PCPNDT compliant — no sex disclosure
- Post-result Genomic Expert consultation
Sample: Maternal Blood only — 10ml in Streck tube. Home collection or nearby lab. No saliva sample needed.
Do you have a doctor's referral?
Yes, I do
No, I don't
No problem! After payment, we'll schedule a pre-test consultation with our Genomic Expert before sample collection.
Quantity
1
Secure checkout · SSL encrypted
Free pan-India shipping
Results in 2–3 weeks
PCPNDT compliant
NABL & CAP accredited
Genomic Expert Consultation — Included
After payment, appointment slot sent. Pre-test consultation if no referral. All high-risk results reviewed personally by our Expert.
Appointment link sent via email after order confirmation.